12 articles for thisTarget
The following articles (labelled with PubMed ID or TBD) are for your review
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Article Title
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Rational drug design approach for overcoming drug resistance: application to pyrimethamine resistance in malaria.
University of Manchester
Analysis of complexes of inhibitors with Cryptosporidium hominis DHFR leads to a new trimethoprim derivative.
Dartmouth College
Three-dimensional quantitative structure-activity relationship analysis of a set of Plasmodium falciparum dihydrofolate reductase inhibitors using a pharmacophore generation approach.
Università
Inhibitors of multiple mutants of Plasmodium falciparum dihydrofolate reductase and their antimalarial activities.
National Center For Genetic Engineering and Biotechnology At Thailand
Target guided synthesis of 5-benzyl-2,4-diamonopyrimidines: their antimalarial activities and binding affinities to wild type and mutant dihydrofolate reductases from Plasmodium falciparum.
National Center For Genetic Engineering and Biotechnology At Thailand
Docking and database screening reveal new classes of Plasmodium falciparum dihydrofolate reductase inhibitors.
Università
Development of 2,4-diaminopyrimidines as antimalarials based on inhibition of the S108N and C59R+S108N mutants of dihydrofolate reductase from pyrimethamine-resistant Plasmodium falciparum.
National Center For Genetic Engineering and Biotechnology At Thailand
Development of a lead inhibitor for the A16V+S108T mutant of dihydrofolate reductase from the cycloguanil-resistant strain (T9/94) of Plasmodium falciparum.
National Center For Genetic Engineering and Biotechnology At Thailand
Discovery of new antimalarial agents: Second-generation dual inhibitors against FP-2 and PfDHFR via fragments assembely.
East China University of Science and Technology
Probing the molecular basis of resistance to pyrimethamine by site-directed mutagenesis.
Pennsylvania State University